1989 - Best Performance by an Actress in a Motion Picture - Drama for The Accused
1992 - Best Performance by an Actress in a Motion Picture - Drama for The Silence of the Lambs
2013 - Cecil B DeMille Award for Outstanding contributions to the world of entertainment

Nominations for: Freaky Friday (1977), Nell (1995), Contact (1998), The Brave One (2008), Carnage (2012)